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Margaret P Chandler Selected Research

Ligation

12/2010Myocardial insulin resistance induced by high fat feeding in heart failure is associated with preserved contractile function.
6/2009Prolonged exposure to high dietary lipids is not associated with lipotoxicity in heart failure.
7/2008Enhanced acyl-CoA dehydrogenase activity is associated with improved mitochondrial and contractile function in heart failure.
9/2007Heart failure progression is accelerated following myocardial infarction in type 2 diabetic rats.
3/2007High-fat diet postinfarction enhances mitochondrial function and does not exacerbate left ventricular dysfunction.
11/2006Dissociation between gene and protein expression of metabolic enzymes in a rodent model of heart failure.

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Margaret P Chandler Research Topics

Disease

16Heart Failure
07/2012 - 04/2002
7Ischemia
01/2006 - 05/2002
6Hypertrophy
07/2013 - 05/2006
6Cardiomegaly (Heart Hypertrophy)
02/2013 - 10/2005
5Infarction (Infarctions)
01/2015 - 05/2006
3Myocardial Infarction
01/2015 - 11/2006
3Hypertension (High Blood Pressure)
04/2007 - 10/2005
2Insulin Resistance
12/2010 - 08/2006
2Stroke (Strokes)
12/2010 - 08/2010
2Ventricular Remodeling
12/2006 - 06/2005
2Left Ventricular Dysfunction
05/2006 - 04/2002
2Hyperglycemia
09/2005 - 05/2003
2Myocardial Ischemia (Ischemic Heart Diseases)
05/2004 - 05/2002
1Type 1 Diabetes Mellitus (Autoimmune Diabetes)
08/2017
1Mitochondrial Diseases (Mitochondrial Disease)
09/2015
1Hypertrophic Cardiomyopathy (Hypertrophic Obstructive Cardiomyopathy)
09/2012
1Starvation
07/2008
1Obesity
03/2007
1Left Ventricular Hypertrophy (Ventricular Hypertrophy, Left)
12/2006
1Cardiomyopathies (Cardiomyopathy)
10/2006
1Stable Angina
07/2003
1Pure Autonomic Failure
05/2002
1Coronary Artery Disease (Coronary Atherosclerosis)
05/2002
1Multiple System Atrophy
05/2002

Drug/Important Bio-Agent (IBA)

24Fatty Acids (Saturated Fatty Acids)IBA
09/2015 - 04/2002
11Glucose (Dextrose)FDA LinkGeneric
07/2012 - 04/2002
8LipidsIBA
05/2014 - 04/2002
7EnzymesIBA
01/2007 - 04/2004
6salicylhydroxamic acid (SHAM)IBA
12/2010 - 05/2006
6Lactic Acid (Lactate)FDA LinkGeneric
12/2005 - 04/2002
5Proteins (Proteins, Gene)FDA Link
12/2010 - 04/2004
5Messenger RNA (mRNA)IBA
07/2008 - 10/2006
5Nonesterified Fatty Acids (NEFA)IBA
04/2007 - 05/2003
4Acyl-CoA Dehydrogenase (Medium-Chain Acyl-Coenzyme A Dehydrogenase)IBA
07/2008 - 05/2006
4CarbohydratesIBA
04/2007 - 04/2002
3Adenosine Triphosphate (ATP)IBA
09/2015 - 12/2005
3Insulin (Novolin)FDA Link
02/2013 - 09/2005
3Atrial Natriuretic Factor (ANF)IBA
09/2007 - 10/2006
3PPAR alphaIBA
04/2007 - 05/2006
3SaltsIBA
04/2007 - 10/2005
32- cyclohexylidenhydrazo- 4- phenyl- thiazoleIBA
01/2007 - 06/2005
3Carnitine (L-Carnitine)FDA LinkGeneric
01/2007 - 07/2003
3TransferasesIBA
01/2007 - 07/2003
3DobutamineFDA LinkGeneric
09/2005 - 05/2002
2Transcription Factors (Transcription Factor)IBA
07/2013 - 11/2006
2Triglycerides (Triacylglycerol)IBA
02/2013 - 05/2006
2Dietary Fats (Dietary Fat)IBA
08/2010 - 12/2006
2Fenofibrate (CiL)FDA LinkGeneric
04/2007 - 05/2006
2CeramidesIBA
03/2007 - 05/2006
2Oxygen (Dioxygen)IBA
05/2005 - 05/2002
24-hydroxyphenylglycine (oxfenicine)IBA
07/2003 - 05/2003
2RanolazineFDA Link
12/2002 - 08/2002
1Methylene Blue (Methylthioninium Chloride)FDA Link
08/2017
1Cardiac MyosinsIBA
09/2012
1Carrier Proteins (Binding Protein)IBA
09/2012
1Glycogen Synthase (Synthase I)IBA
12/2010
1Acyl-CoA DehydrogenasesIBA
07/2008
1Actins (F Actin)IBA
09/2007
1FructoseIBA
04/2007
1Starch (Cornstarch)IBA
04/2007
1MonosaccharidesIBA
04/2007
1para- trifluoro- methyl- 5- phenyl- 1,2,4- oxadiazoleIBA
02/2007
1CatecholaminesIBA
01/2007
1Isoproterenol (Isoprenaline)FDA LinkGeneric
01/2007
1Myosin Heavy Chains (Myosin Heavy Chain)IBA
12/2006
1Citrate (si)-Synthase (Synthase, Citrate)IBA
12/2006
1Peroxisome Proliferator-Activated Receptors (PPAR)IBA
11/2006
1Retinoid X Receptor alphaIBA
11/2006
1Trimetazidine (Vastarel)IBA
10/2006
1Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA
05/2006
1hexanoic acid (hexanoate)IBA
01/2006
1FumaratesIBA
01/2006
1Citric Acid (Citrate)FDA LinkGeneric
01/2006
1Succinic Acid (Succinate)IBA
01/2006
1malic acid (malate)IBA
01/2006
1malonyl-CoA decarboxylaseIBA
12/2005
1Oxidoreductases (Dehydrogenase)IBA
12/2005
1Pyruvic Acid (Pyruvate)IBA
12/2005
1Malonyl Coenzyme A (Malonyl CoA)IBA
12/2005
1Adrenergic Agents (Adrenergic Drugs)IBA
12/2005
1Proto-Oncogene Proteins c-akt (Protein Kinase B)IBA
09/2005
1Nitroglycerin (Dynamite)FDA LinkGeneric
05/2005
1Nitric Oxide Synthase (NO Synthase)IBA
05/2005
1Oleic Acid (Oleate)IBA
07/2003
1GlycogenIBA
05/2002

Therapy/Procedure

6Ligation
12/2010 - 11/2006
2Therapeutics
01/2015 - 04/2002
1Cell Transplantation
01/2015
1Fat-Restricted Diet (Diet, Fat Restricted)
12/2006
1Sympathectomy (Sympathectomies)
05/2002